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World J Gastroenterol. Jul 7, 2014; 20(25): 8201-8208
Published online Jul 7, 2014. doi: 10.3748/wjg.v20.i25.8201
Published online Jul 7, 2014. doi: 10.3748/wjg.v20.i25.8201
DNA methyltransferase3a expression is an independent poor prognostic indicator in gastric cancer
Xue-Yuan Cao, Jian Suo, Department of Gastric and Colorectal Surgery, First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Hong-Xi Ma, Mei-Shan Jin, Yin-Ping Wang, Division of Pathology, First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Yan-Hong Shang, Department of Oncology, Affiliated Hospital of Hebei University, Baoding 071000, Hebei Province, China
Fei Kong, Zhi-Fang Jia, Dong-Hui Cao, Jing Jiang, Division of Clinical Epidemiology, First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Author contributions: Jiang J and Cao XY designed the study and carried out most of the study; Cao XY, Shang YH and Jiang J wrote the first draft of manuscript; Ma HX, Jin MS, and Wang YP analyzed pathological data; Kong F, Jia ZF and Cao DH collected patients’ clinical information; Jia ZF and Jiang J performed statistical analysis; Suo J provided valuable suggestions for the study.
Supported by Norman Bethune Program of Jilin University, No. 2013025; and National Natural Science Foundation of China, No. 81072369 and No. 81273065
Correspondence to: Jing Jiang, MD, PhD, Division of Clinical Epidemiology, First Hospital of Jilin University, No. 71 Xinming Dajie, Changchun 130021, Jilin Province, China. jiangjing19702000@jlu.edu.cn
Telephone: +86-431-81875408 Fax: +86-431-88782889
Received: January 13, 2014
Revised: February 8, 2014
Accepted: April 1, 2014
Published online: July 7, 2014
Processing time: 171 Days and 5.1 Hours
Revised: February 8, 2014
Accepted: April 1, 2014
Published online: July 7, 2014
Processing time: 171 Days and 5.1 Hours
Core Tip
Core tip: Up to now, few studies investigated the expression of DNA methyltransferases (DNMTs) and the relationship between their expression and histopathology in gastric cancer. In this article, DNMT1, DNMT3a and DNMT3b expression has been investigated in 307 gastric cancer patients. The results suggest that expression of DNMT3a is an independent poor prognostic indicator in gastric cancer. DNA methylation plays essential roles in the development of gastric cancer.