Association of human leukocyte antigen DQB1 and DRB1 alleles with chronic hepatitis B

Figure 1 Sequence similarity analysis of the β subdomain of three different major histocompatibility complex class II proteins. An asterisks underneath a capital letter denotes a single, fully conserved residue. The semicolons and dots represent amino acids with conservation of strong groups or weak groups, respectively. For a mismatch between amino acids, a space is left underneath. The residues determined to be important for T-cell receptor recognition are shown with yellow shading.

Figure 2 Possible model illustrating the single-nucleotide polymorphic regions of major histocompatibility complex class II that affect T-cell receptor recognition. The yellow asterisks show mutational sites that are buried in the peptide-binding pocket, whereas the white asterisks indicate mutations in the solvent-exposed T-cell recognition regions. This model was built according to the available crystal structures, which were published previously[41].