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World J Gastroenterol. Jul 7, 2014; 20(25): 8179-8186
Published online Jul 7, 2014. doi: 10.3748/wjg.v20.i25.8179
Published online Jul 7, 2014. doi: 10.3748/wjg.v20.i25.8179
Association of human leukocyte antigen DQB1 and DRB1 alleles with chronic hepatitis B
Levent Doganay, Feruze Yilmaz Enc, Yasar Colak, Celal Ulasoglu, Ilyas Tuncer, Department of Gastroenterology, Goztepe Teaching and Research Hospital, Medeniyet University, Istanbul 34722, Turkey
Levent Doganay, Oguzhan Ozturk, Department of Gastroenterology, Umraniye Teaching and Research Hospital, Istanbul 34760, Turkey
Arta Fejzullahu, Seyma Katrinli, Gizem Dinler Doganay, Department of Molecular Biology and Genetics, Istanbul Technical University, Istanbul 34469, Turkey
Author contributions: Doganay L and Dinler Doganay G equally contributed to this study; Doganay L, Dinler Doganay G, Fejzullahu A, Katrinli S and Tuncer I designed the research; Doganay L, Yilmaz Enc F, Ozturk O, Colak Y and Ulasoglu C collected the clinical data; Doganay L and Yilmaz Enc F collected the patients’ specimens; Dinler Doganay G, Fejzullahu A and Katrinli S performed the research; Doganay L and Dinler Doganay G analyzed the data; Doganay L and Dinler Doganay G wrote the paper.
Supported by Internal research funds of Istanbul Technical University, No. 36403
Correspondence to: Gizem Dinler Doganay, PhD, Associate Professor, Department of Molecular Biology and Genetics, Istanbul Technical University, Istanbul 34469, Turkey. gddoganay@itu.edu.tr
Telephone: +90-212-2857249 Fax: +90-212-2856386
Received: December 12, 2013
Revised: February 17, 2014
Accepted: April 1, 2014
Published online: July 7, 2014
Processing time: 202 Days and 21.1 Hours
Revised: February 17, 2014
Accepted: April 1, 2014
Published online: July 7, 2014
Processing time: 202 Days and 21.1 Hours
Core Tip
Core tip: Chronic hepatitis B is a major health problem worldwide. Recent genome-wide association studies revealed a significant association between the human leukocyte antigen (HLA) class II region and chronic hepatitis B. In the present study, we genotyped HLA DQB1 and DRB1 alleles in 355 chronic hepatitis B patients and investigated the effects of the HLA alleles on disease activity and cirrhosis development. We found that DQB1*05:01 was a risk factor for chronic active hepatitis and that DRB1*07 was a protective factor against cirrhosis. A bioinformatics analysis revealed that DRB1*07 might be associated with a hypoimmune response.