Huge undifferentiated carcinoma of the pancreas with osteoclast-like giant cells

Figure 1 Huge undifferentiated carcinoma with osteoclast-like giant cells. A: Computed tomography scans revealed the tumor occupying the lesser sac; B: Tumor arose from the pancreas body and invaded directly the stomach wall and transverse mesocolon.

Figure 2 Histopathological characteristics. A: Tumor was composed of highly pleomorphic neoplastic cells and non-neoplastic osteoclast-like giant cells. Hematoxylin and eosin (H and E), × 100; B: Ductal adenocarcinoma component was also found in some areas. H and E, × 40.

Figure 3 Immunohistochemical staining. A: Reactivity with cytokeratin in ductal adenocarcinoma component; B: Reactivity with vimentin in pleomorphic neoplastic cells; C: Reactivity with CD68 in osteoclast-like giant cells; D: Reactivity with p53 in tumor cells.