HEF-19-induced relaxation of colonic smooth muscles and the underlying mechanisms

Figure 1 3. 4-dihydro-7-[3-(diethylamino) propoxy] chroman hydrochloride.

Figure 2 Effects of HEF-19 on spontaneous tension and amplitude of isolated rabbit descending colonic smooth muscle.

Figure 3 Relaxant effect of HEF-19 (3 × 10^-7-3 × 10^-4 mol/L) on isolated rabbit descending colonic smooth muscle pre-contracted with Ach, histamine, high-K⁺ solution or BaCl₂. Data are mean ± SE (n = 6).

Figure 4 Effect of HEF-19 and verapamil on the contraction-response curve of CaCl₂ in descending colonic smooth muscle isolated from rabbits. Data are mean ± SE (n = 6) and are expressed as percentage of maximum contraction.

Figure 5 Effects of HEF-19 (3 × 10^-6 and 10^-5 mol/L) and verapamil (1 × 10^-7 mol/L) on biphasic contraction induced by Ach in descending colonic smooth muscle isolated from rabbits. Data are mean ± SE (n = 6). ^aP < 0.05, ^bP < 0.01 vs the controls.