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World J Gastroenterol. Aug 28, 2013; 19(32): 5314-5319
Published online Aug 28, 2013. doi: 10.3748/wjg.v19.i32.5314
Published online Aug 28, 2013. doi: 10.3748/wjg.v19.i32.5314
HEF-19-induced relaxation of colonic smooth muscles and the underlying mechanisms
Yuan-Yuan Wei, Lu-Lu Sun, Department of Pharmacy, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China
Shou-Ting Fu, School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning Province, China
Author contributions: Wei YY performed the research and drafted the paper; Sun LL provided advice regarding the performance of research and revision of the paper; Fu ST designed the research and revised the paper.
Correspondence to: Dr. Lu-Lu Sun, Department of Pharmacy, Beijing Shijitan Hospital, Capital Medical University, No. 10, Tieyi Road, Haidian District, Beijing 100038, China. yuan2wei1@163.com
Telephone: +86-24-63926036 Fax: +86-24-63926038
Received: May 27, 2013
Revised: July 1, 2013
Accepted: July 12, 2013
Published online: August 28, 2013
Revised: July 1, 2013
Accepted: July 12, 2013
Published online: August 28, 2013
Core Tip
Core tip: This is a good descriptive study in which authors found a new L-calcium-antagonist relaxing rabbit colonic smooth muscles and analyzed its possible mechanism. It provides an opportunity to search for a new drug highly selective to the gastrointestinal tract, effectively relieving pain, diarrhea and intestinal discomfort, but without significant adverse effects on irritable bowel syndrome patients.