Endoscopic appearance of AIDS-related gastrointestinal lymphoma with c-MYC rearrangements: Case report and literature review

Figure 1 Upper and lower gastrointestinal endoscopic findings. A: Multiple elevated lesions in the body of the stomach; B: Multiple dish-like lesions with bleeding dyed with indigo carmine; C: Bloody spots in the body of the stomach; D: Ulceration with bleeding in the upper body of the stomach; E: Narrow band imaging (NBI) with magnification showing a honeycomb-like pattern at the edge of the elevated lesion; F: Irregular microsurface pattern in ulceration with NBI; G: Erythematous flat lesions in the duodenum; H: Multiple nodular masses in the colon and rectum.

Figure 2 Histological findings and immunostaining of the biopsy specimen. Pleomorphic, atypical lymphoid cells with eosinophilic cytoplasm, marked nucleoli, and vesicular nuclei with hematoxylin and eosin staining (× 10). Immunohistochemistry shows positive staining for CD20 (× 4), CD30 (× 20), CD38 (× 10), CD79a (× 20), EMA (× 10), LMP-1 (× 10), MUM-1 (× 10), and BCL2 (× 10). Biopsy specimens revealed positive EBER-in situ hybridization (× 40). LMP-1: Latent membrane protein 1; MUM-1: Multiple myeloma oncogene 1; EMA: Epithelial membrane antigen.