Case Report
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World J Gastroenterol. Aug 7, 2013; 19(29): 4827-4831
Published online Aug 7, 2013. doi: 10.3748/wjg.v19.i29.4827
Endoscopic appearance of AIDS-related gastrointestinal lymphoma with c-MYC rearrangements: Case report and literature review
Shohei Tanaka, Naoyoshi Nagata, Sohtaro Mine, Toru Igari, Taiichiro Kobayashi, Jun Sugihara, Haruhito Honda, Katsuji Teruya, Yoshimi Kikuchi, Shinichi Oka, Naomi Uemura
Shohei Tanaka, Naoyoshi Nagata, Department of Gastroenterology and Hepatology, National Center for Global Health and Medicine, Tokyo 162-8655, Japan
Sohtaro Mine, Toru Igari, Clinical Laboratory and Pathology, National Center for Global Health and Medicine, Tokyo 162-8655, Japan
Taiichiro Kobayashi, Jun Sugihara, Haruhito Honda, Katsuji Teruya, Yoshimi Kikuchi, Shinichi Oka, Division of AIDS Clinical Center, National Center for Global Health and Medicine, Tokyo 162-8655, Japan
Naomi Uemura, Department of Gastroenterology and Hepatology, National Center for Global Health and Medicine, Kohnodai Hospital, Chiba 272-0827, Japan
Author contributions: Tanaka S and Nagata N contributed equally to this work; Nagata N, Kobayashi T, Sugihara J, Honda H, Teruya K, Kikuchi Y, Oka S and Uemura N helped to edit the manuscript; Mine S and Igari T provided discussion of the pathological features; Tanaka S and Nagata N wrote of the paper.
Supported by The National Center for Global Health and Medicine
Correspondence to: Dr. Naoyoshi Nagata, MD, Department of Gastroenterology and Hepatology, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan. nnagata_ncgm@yahoo.co.jp
Telephone: +81-3-32027181 Fax: +81-3-32071038
Received: March 16, 2013
Revised: May 12, 2013
Accepted: June 19, 2013
Published online: August 7, 2013
Processing time: 143 Days and 8.5 Hours
Core Tip

Core tip: Endoscopic findings in gastrointestinal-acquired immune deficiency syndrome (GI-AIDS) related lymphoma (ARL) are miscellaneous and may be different from non-AIDS GI lymphoma. We report a rare case of GI-ARL with MYC rearrangements and coinfected with Epstein-Barr virus infection, and there are multiple findings involving stomach, duodenum, and colon and rectum. Magnified endoscopy with narrow band imaging showed a honeycomb-like pattern without irregular microvessels in the dish-like lesions of the stomach. Moreover we conducted literature review of GI-ARL. To our knowledge, this is the first report of GI-ARL with MYC arrangements and presenting an atypical endoscopic appearances.