Increased expression of matrix metalloproteinase-9 associated with gastric ulcer recurrence

Figure 1 Production of matrix metalloproteinase-9 or tissue inhibitor of metalloproteinase-1 by gastric mucosa in patients with gastric ulcer (n = 63) or chronic superficial gastritis (n = 25). A: Tissue culture was performed for 24 h. Matrix metalloproteinase (MMP)-9 concentration in tissue culture supernatants was measured by enzyme-linked immunosorbent assay (ELISA); B: Tissue inhibitor of metalloproteinase (TIMP)-1 concentration in tissue culture supernatants was measured by ELISA. GU: Gastric ulcer; CSG: Chronic superficial gastritis.

Figure 2 Correlation between matrix metalloproteinase-9 or tissue inhibitor of metalloproteinase-1 production by gastric mucosa in gastric ulcer patients (n = 63). Linear regression analysis showed a significant correlation between the two mediators (r = 0.29, P = 0.021). A significant positive correlation was observed between levels of matrix metalloproteinase (MMP)-9 and tissue inhibitor of metalloproteinase (TIMP)-1 at the ulcer site.

Figure 3 Production of matrix metalloproteinase-9 or tissue inhibitor of metalloproteinase-1 by gastric mucosa with negative or positive H. pylori-infection in patients with gastric ulcer (n = 63) or chronic superficial gastritis (n = 25). A: Tissue culture was performed for 24 h. Matrix metalloproteinase (MMP)-9 concentration in tissue culture supernatants was measured by enzyme-linked immunosorbent assay (ELISA); B: Tissue culture was performed for 24 h. Tissue inhibitor of metalloproteinase (TIMP)-1 concentration in tissue culture supernatants was measured by ELISA. GU: Gastric ulcer; CSG: Chronic superficial gastritis; H. pylori: Helicobacter pylori.