Effect of DA-9701 on gastric emptying in a mouse model: Assessment by 13C-octanoic acid breath test

Figure 1 Typical excretion curve of the ¹³C-octanoic acid breath test in the mouse model. m: The total cumulative ¹³C recovery when time is infinite; T_1/2: Half gastric emptying time; T_lag10: Lag phase of 10 % emptying; T_lag15: Lag phase for 15% emptying.

Figure 2 Reproducibility of the ¹³C-octanoic acid breath test in ten mice.

Figure 3 Mean excretion curve of the ¹³C-octanoic acid breath test in mice treated with DA-9701, erythromycin, and saline. m: The total cumulative ¹³C recovery when time is infinite. ^aP < 0.05 between DA-9701 and saline.

Figure 4 Half gastric emptying time and lag phase for 15% emptying measured by the ¹³C-octanoic acid breath test in the each mouse treated with DA-9701, erythromycin, and saline. A: Half gastric emptying time (T_1/2); B: Lag phase for 15% emptying (T_log15). ^aP < 0.05 vs saline.