Brief Article
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World J Gastroenterol. Jul 21, 2013; 19(27): 4380-4385
Published online Jul 21, 2013. doi: 10.3748/wjg.v19.i27.4380
Effect of DA-9701 on gastric emptying in a mouse model: Assessment by 13C-octanoic acid breath test
Chul-Hyun Lim, Myung-Gyu Choi, Hyeyeon Park, Myong Ki Baeg, Jae Myung Park
Chul-Hyun Lim, Myung-Gyu Choi, Hyeyeon Park, Myong Ki Baeg, Jae Myung Park, Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul 137-070, South Korea
Author contributions: Lim CH and Choi MG designed the study; Lim CH and Park H performed animal experiments; Lim CH and Park JM collected data, analyzed the results of the statistical analyses; Lim CH, Choi MG, and Baeg MK wrote and edited the paper, and approved the final version.
Supported by the Global Leading Technology Program of the Office of Strategic R and D Planning funded by the Ministry of Knowledge Economy, South Korea, No. 10039321; Seoul St. Mary’s Clinical Medicine Research Program year of 2011 through the Catholic University of Korea
Correspondence to: Myung-Gyu Choi, MD, Department of Internal Medicine, The Catholic University of Korea College of Medicine, 505 Banpo-dong, Seocho-gu, Seoul 137-070, South Korea. choim@catholic.ac.kr
Telephone: +82-2-22586017 Fax: +82-2-22582038
Received: March 18, 2013
Revised: May 10, 2013
Accepted: May 16, 2013
Published online: July 21, 2013
Processing time: 124 Days and 4.4 Hours
Core Tip

Core tip: DA-9701 is a newly formulated prokinetic agent obtained from extracts of Pharbitis Semen and Corydalis Tuber. The 13C-octanoic acid breath test is a reliable and responsive method for measuring gastric emptying in small laboratory animal. This technique can be performed repeatedly in the same animal and reflect exact pharmacological effects without sacrifice of the animal. This study demonstrated the gastrokinetic effects of DA-9701, using repeated 13C-octanoic acid breath tests in the same animal. The gastrokinetic effect of DA-9701 could have therapeutic potential for the treatment of familial dysautonomia.