Patatin-like phospholipase domain containing-3 gene I148M polymorphism, steatosis, and liver damage in hereditary hemochromatosis

Figure 1 Study flow chart. C282Y+/+ HH: Homozygous for the C282Y HFE mutation of hereditary hemochromatosis; M/F: Male/female; BMI: Body mass index.

Figure 2 Frequency distribution of the rs738409 C > G single nucleotide polymorphism, encoding for the I148M protein variant, in 123 patients with homozygous for the C282Y HFE mutation of hereditary hemochromatosis subdivided according to the presence of steatosis (P = 0. 015).

Figure 3 Effect of the rs738409 G allele, encoding for the 148M PNPLA3 variant, on liver cirrhosis in 174 patients with HH subdivided according to the presence of overweight. NS: Not significant; BMI: Body mass index.