Breviscapine attenuates acute pancreatitis by inhibiting expression of PKCα and NF-κB in pancreas

Figure 1 Effect of breviscapine on mortality (A), ascites volume (B) and amylase activity (C), morphological change (D), morphological score (E), and malondialdehyde level (F) in rats with acute pancreatitis. ^aP < 0.05, ^bP< 0.01 vs SO group; ^cP < 0.05, ^dP < 0.01 vs ANP group. Bre: Breviscapine; SO: Sham operation; ANP: Acute necrotizing pancreatitis; MDA: Malondialdehyde.

Figure 2 Immunohistochemical analysis showing expression of protein kinase C alpha (PKCα) (A) and nuclear factor (NF)-κB P65 (B) in cytoplasm, membrane or nuclei of acini and inflammatory cells in pancreas, and western blotting showing the expression level of PKCα and NF-κB P65 in breviscapine and acute necrotizing pancreatitis groups at different time points (C). Bre: Breviscapine; SO: Sham operation; ANP: Acute necrotizing pancreatitis.