Clinicopathological significance and prognostic value of LRP16 expression in colorectal carcinoma

Figure 1 Positive leukemia related protein 16 (LRP16) expression in colorectal adenocarcinoma. The final score was 6, including 3 scores (strong) related to intensity of staining and 3 scores (> 50%) related to extent of staining. Thus it was defined as strong staining pattern (++). A: Immunohistochemistry (IHC), × 100; B: IHC, × 400.

Figure 2 Negative LRP16 expression in normal colorectal mucosa (IHC, × 400). The final score was 0, including 0 score (negative) related to intensity of staining, and 0 scores (< 5%) related to extent of staining. Thus it was defined as negative expression (-).

Figure 3 Cumulative survival according to LRP16 expression in colorectal cancer patients. The Kaplan-Meier plot of colorectal carcinoma patients (n = 201) demonstrates a significantly lower survival with LRP16 positive expression, P = 0.001.