Brief Article
Copyright ©2010 Baishideng. All rights reserved.
World J Gastroenterol. Apr 7, 2010; 16(13): 1644-1648
Published online Apr 7, 2010. doi: 10.3748/wjg.v16.i13.1644
Clinicopathological significance and prognostic value of LRP16 expression in colorectal carcinoma
Hong-Qing Xi, Po Zhao, Wei-Dong Han
Hong-Qing Xi, Po Zhao, Department of Pathology, Chinese People’s Liberation Army General Hospital, Beijing 100853, China
Wei-Dong Han, Department of Molecular Biology, Institute of Basic Medicine, Chinese People’s Liberation Army General Hospital, Beijing 100853, China
Author contributions: Xi HQ performed the research and wrote the manuscript; Zhao P designed the research and was also involved in editing the manuscript; Han WD provided some reagents and analytical tools.
Supported by (in part) Grant from the Ministry of Science and Technology of China, No. 2010 CB912802
Correspondence to: Dr. Po Zhao, Department of Pathology, Chinese People’s Liberation Army General Hospital, 28 Fuxing Road, Beijing 100853, China. zhaopo@301hospital.com.cn
Telephone: +86-10-66937736 Fax: +86-10-68181689
Received: December 28, 2009
Revised: February 1, 2010
Accepted: February 8, 2010
Published online: April 7, 2010
Abstract

AIM: To explore the expression of leukemia related protein 16 (LRP16) in colorectal carcinoma, and analyze its correlation with clinicopathologic features and prognosis.

METHODS: Immunohistochemistry for LRP16 was performed in 201 cases of colorectal carcinoma and 60 cases of distal normal mucosa. Medical records were reviewed and clinicopathological analysis was performed.

RESULTS: LRP16 expression was detected in 117 of 201 cases of the colorectal carcinoma and in 21 cases of 60 distal normal mucosa. The expression of LRP16 in carcinoma was significantly higher than that in normal mucosa (χ2 = 9.999, P = 0.002). LRP16 protein expression was found in 43.3% (52/120) of carcinoma at stage I and II, and 80.2% (65/81) of carcinoma at stage III and IV (χ2 =27.088, P = 0.001). Correlation between LRP16 expression and clinicopathological factors was significant in differentiation (P = 0.010), tumor size (P = 0.001), infiltrative depth (P = 0.000) and distant metastasis (P = 0.027). The difference of median survival time between cancer patients with LRP16 expression (38.0 mo) and those without was statistically significant (105.0 mo, Log rank = 41.455, P = 0.001). The multivariate survival analysis revealed that LRP16 expression was correlated significantly (Cox’s regression: P = 0.001, relative risk = 2.082) with shortened survival in the patients with colorectal cancer.

CONCLUSION: The expression of LRP16 is related to the degree of differentiation, invasiveness, metastasis and prognosis of colorectal carcinoma.

Keywords: Colorectal neoplasms; Immunohistochemistry; Leukemia related protein 16; Prognosis; Clinicopathology