Mechanisms of resistance to anti-EGFR monoclonal antibody treatment in metastatic colorectal cancer

doi:10.3748/wjg.v16.i10.1177

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Mar 14, 2010 (publication date) through Jan 6, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 14, 2010; 16(10): 1177-1187
Published online Mar 14, 2010. doi: 10.3748/wjg.v16.i10.1177

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Figure 1 Simplified illustration of the epidermal growth factor receptor (EGFR) pathway with the RAS/MAPK and PIK3CA/PTEN cascades. Specific components of the pathway are correlated with resistance to anti-EGFR monoclonal antibodies (moAbs). As shown, KRAS and BRAF mutations are correlated with resistance to anti-EGFR moAbs, while further evaluation is required for PIK3CA mutations and PTEN loss of expression.

Citation: Saridaki Z, Georgoulias V, Souglakos J. Mechanisms of resistance to anti-EGFR monoclonal antibody treatment in metastatic colorectal cancer. World J Gastroenterol 2010; 16(10): 1177-1187
URL: https://www.wjgnet.com/1007-9327/full/v16/i10/1177.htm
DOI: https://dx.doi.org/10.3748/wjg.v16.i10.1177