Comparative study of omeprazole, lansoprazole, pantoprazole and esomeprazole for symptom relief in patients with reflux esophagitis

Figure 1 Study protocol.

Figure 2 Daily changes in mean heartburn score for all subjects on each proton pump inhibitor regimen. (◆) Subjects administered omeprazole (n = 68), (■) Subjects administered lansoprazole (n = 69), (▲) Subjects administered pantoprazole (n = 69), (●) Subjects administered esomeprazole (n = 68). Significant difference between the omeprazole, lansoprazole, pantoprazole, and esomeprazole after 1 d drug administration (P = 0.0031, 0.0039, 0.0009, respectively). ○ significant difference between the omeprazole, lansoprazole, pantoprazole and esomeprazole after 2 d drug administration (P = 0.0092, 0.0088, 0.0036, respectively).

Figure 3 Daily changes in mean acid regurgitation score for all subjects on each proton pump inhibitor regimen. There were no significant differences between the (◆) omeprazole (n = 68), (■) lansoprazole (n = 69), (▲) pantoprazole (n = 69), and (●) esomeprazole (n = 68) groups after drug administration.

Figure 4 Daily changes in mean heartburn score for all subjects on each proton pump inhibitor regimen, considering only subjects with symptoms prior to commencement of test-drug administration. (◆) Subjects administered omeprazole (n = 61), (■) Subjects administered lansoprazole (n = 63), (▲) Subjects administered pantoprazole (n = 62), (●) Subjects administered esomeprazole (n = 63). △1-5 significant difference between the omeprazole, lansoprazole, pantoprazole and esomeprazole after 1-5 d drug administration, P = 0.0018, 0.0020, 0.0006, respectively, P = 0.0098, 0.0046, 0.0005, respectively, P = 0.0027, 0.0037, 0.0009, respectively, P = 0.0137, 0.0016, 0.0031, respectively, P = 0.0069, 0.0076, 0.0119, respectively.

Figure 5 Daily changes in mean acid regurgitation score for considering only subjects with symptoms prior to commencement of test drug administration. There were no significant differences between the (◆) omeprazole (n = 33), (■) lansoprazole (n = 35), (▲) pantoprazole (n = 34), and (●) esomeprazole (n = 35) groups after drug administration.

Figure 6 Daily changes in mean heartburn score in H pylori-positive and -negative of all subjects with test drug administration. (●) H pylori-negative subjects (n = 155), (■) H pylori-positive subjects (n = 119), There was no significant difference between H pylori-positive and H pylori-negative subjects after test drug administration.

Figure 7 Daily changes in mean heartburn score in H pylori-positive and -negative subjects with heartburn prior to test drug administration. (▲) H pylori-negative subjects (n = 140), (●) H pylori-positive subjects (n = 109), There was no significant difference between H pylori-positive and H pylori-negative subjects after test drug administration.