Acute effects of Helicobacter pylori extracts on gastric mucosal blood flow in the mouse

Figure 1 Blood flow measurements in control group (n = 5) and in animals exposed to HPE (n = 6). Mean arterial blood pressure (MAP) is expressed in mmHg, and blood flow (LDF) and vascular resistance (R) in percent of the control period at time-points 5-10 min. The mucosa was exposed to HPE for 40 min. Values are mean ± SE. ^aP < 0.05 compared with control period in HPE-treated animals.

Figure 2 Blood flow measurements in the lidocaine control group (n = 6), and in animals treated with lidocaine and HPE (n = 6). Mean arterial blood pressure (MAP) is expressed in mmHg, and blood flow (LDF) and vascular resistance (R) in percent of the values of the control period at time-points 5-10 min. The mucosa was exposed to lidocaine for 10 min before the control period started, and then to lidocaine with or without HPE for 40 min. Values are mean ± SE. ^aP < 0.05 compared with the control period in control animals, ^cP < 0.05 compared with control period in HPE-treated animals.

Figure 3 Blood flow measurements in iNOS wild type (n = 6), and iNOS-/- mice (n = 6), both exposed to HPE. Mean arterial blood pressure (MAP) is expressed in mm Hg, and blood flow (LDF) and vascular resistance (R) in percent of the values in the control period, at time-points 5-10 min. The mucosa was exposed to HPE for 40 min. Values are mean ± SE. ^aP < 0.05 compared with the control period in control animals, ^cP < 0.05 compared with control period in iNOS-/- animals.

Figure 4 Blood flow measurements in the ADMA control group (n = 5-6), and iNOS-/- mice treated with ADMA (n = 5). Mean arterial blood pressure (MAP) is expressed in mm Hg, and blood flow (LDF) and vascular resistance (R) in percent of the control period at time-points 5-10 min. The mucosa was exposed to 500 &mgr;mol/L ADMA for 40 min. Values are mean ± SE. ^aP < 0.05 compared with the control period.