Resveratrol attenuates oxidative stress and histological alterations induced by liver ischemia/reperfusion in rats

Figure 1 Effects of liver I/R and resvera-trol on liver function. A: The AST values; B: The ALT values ^aP < 0.05 compared with Group 1 and 2; ^cP < 0.05 compared with Group 3. The values are the mean ± SE. ALT: Alanine aminotransferase; AST: Aspartate aminotransferase.

Figure 2 Effects of ischemia/reperfusion and resveratrol on the MDA (A), SOD (B), CAT (C), and GSH (D) levels in liver tissue. ^aP < 0.05 compared with groups 1 and 2. ^cP < 0.05 compared with group 3. The values are the mean ± SE. MDA: Malondialdehyde; SOD: Superoxide dismutase; CAT: Catalase; GSH: Glutathione peroxidase.

Figure 3 Effect of resveratrol on hepatic tissue injury after I/R evaluated by histological examination. In groups 1 and 2, normal findings were obtained on histological examination (A and B, respectively) (HE, × 200); C: In group 3, swollen hepatocytes with marked vacuolization and congestion were observed (HE, × 200); D: In group 4, the hepatocytes and sinusoids showed normal morphology, reflecting a well preserved liver parenchyma (HE, × 200).