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World J Gastroenterol. Dec 14, 2008; 14(46): 7101-7106
Published online Dec 14, 2008. doi: 10.3748/wjg.14.7101
Resveratrol attenuates oxidative stress and histological alterations induced by liver ischemia/reperfusion in rats
Ercan Gedik, Sadullah Girgin, Hayrettin Ozturk, Basra Deniz Obay, Hulya Ozturk, Huseyin Buyukbayram
Ercan Gedik, Sadullah Girgin, Department of General Surgery, Medical School, Dicle University, Diyarbakir 21280, Turkey
Hayrettin Ozturk, Department of Pediatric Surgery, Medical School, Abant Izzet Baysal University, Bolu, Turkey
Basra Deniz Obay, Department of Physiology, Medical School, Dicle University, Diyarbakir 21280, Turkey
Hulya Ozturk, Department of Pediatric Surgery, Medical School, Duzce University, Bolu, Turkey
Huseyin Buyukbayram, Department of Pathology, Medical School, Dicle University, Diyarbakir 21280, Turkey
Author contributions: All of the authors contributed equally to this work.
Correspondence to: Ercan Gedik, Assistant Professor in General Surgery, Department of General Surgery, Medical School, Dicle University, Diyarbakir 21280, Turkey. ercan.gedik@yahoo.com.tr
Telephone: +90-412-2488001-4679 Fax: + 90-412-2488440
Received: September 18, 2008
Revised: October 13, 2008
Accepted: October 20, 2008
Published online: December 14, 2008
Abstract

AIM: To investigate the effects of resveratrol on liver ischemia/reperfusion (I/R) injury in rats.

METHODS: A total of 40 male Sprague-Dawley rats weighing 240-290 g were randomized into four groups of ten: (1) controls: data from unmanipulated animals; (2) sham group: rats subjected to the surgical procedure, except for liver I/R, and given saline; (3) I/R group: rats underwent liver ischemia for 45 min followed by reperfusion for 45 min; (4) I-R/Resveratrol group: rats pretreated with resveratrol (10 μmol/L, iv). Liver tissues were obtained to determine antioxidant enzyme levels and for biochemical and histological evaluation.

RESULTS: Plasma aminotransferase activities were higher in the I/R group than in the I-R/Resveratrol group. Malondialdehyde levels and the hepatic injury score decreased, while superoxide dismutase, catalase, and glutathione peroxidase levels increased in group 4 compared to group 3. In group 4, histopathological changes were significantly attenuated in resveratrol-treated livers.

CONCLUSION: These results suggest that resveratrol has protective effects against hepatic I/R injury, and is a potential therapeutic drug for ischemia reperfusion-related liver injury.

Keywords: Injury; Ischemia/reperfusion; Liver; Resveratrol