Rectal administration of d-alpha tocopherol for active ulcerative colitis: A preliminary report

Figure 1 Specific instrument for enema (Enema irrigator disposable). Fifteen mL of the liquid vitamin E was rectally administered in our patients using this disposable enema irrigator.

Figure 2 Individual changes in disease activity from week 0 to 12, assessed by the Mayo Disease Activity Index, in subjects who received d-α Tocopherol enema. One patient who was withdrawn early from the study is not included. There was a significant decrease in the mean DAI score for patients after 4th and 12th weeks of therapy (P < 0.0001).

Figure 3 Change in the modified DAI. A modified DAI score, including all components of the complete DAI other than the endoscopic appearance is calculated at each observation point. By week 4 the mean modified DAI score significantly decreased compared to baseline (week 0) scores. ^aP < 0.0001 vs baseline.

Figure 4 Individual changes in ESR from week 0 to 12, in our patients. There was a significant decrease in the mean ESR on the 8th and the 12th week of therapy compared to the beginning of the study. ^aP < 0.0001 vs baseline (0 wk).