Permeabilities of rebamipide via rat intestinal membranes and its colon specific delivery using chitosan capsule as a carrier

Figure 1 Time course of M-S and S-M transport of rebamipide across the different intestinal tissues. Each value represents mean ± SE (n = 10).

Figure 2 The Papps of rebamipide across the different intestinal regions. Each value represents mean ± SE (n = 10). ^bP < 0.01 vs colon M-S, ^dP < 0.01 vs colon S-M, ^aP < 0.05 vs ileum S-M.

Figure 3 Time course of transport of rebamipide across the colonic tissues in the presence of various concentrations of C12. Each value represents mean ± SE (n = 10).

Figure 4 Effect of verious concentrations of C12 on the Papps of rebamipide in the colonic tissues. Each value represents mean ± SE (n = 10). ^aP < 0.05, ^bP < 0.01 vs control.

Figure 5 Time course of transport of rebamipide across the colonic tissues in the presence of various concentrations of labrasol. Each value represents mean ± SE (n = 10).

Figure 6 Effect of various concentrations of labrasol on the Papps of rebamipide in the colonic tissues. Each value represents mean ± SE (n = 10). ^aP < 0.05, ^bP < 0.01 vs control.

Figure 7 Release of rebamipide from chitosan capsules or gelatin capsules by Japanese pharmacopoeia rotating basket method (n = 6). 0-2 h: In the artificial gastric juice; 2-6 h: In the artificial small intestinal juice.

Figure 8 Concentration-time profiles of rebamipide in the colon tissue after oral administration to rat with various dosage forms. Each value represents mean ± SE (n = 3).

Figure 9 Plasma concentration-time profiles of rebamipide after oral administration to rat with various dosage forms. Each value represents mean ± SE (n = 3).

Figure 10 Concentration-time profiles of rebamipide in the colon tissue after oral administration to rat with or without C12. Each value represents mean ± SE (n = 3).

Figure 11 Plasma concentration-time profiles of rebamipide after oral administration to rat with or without C12. Each value represents mean ± SE (n = 3).