Up-regulation of α-catenin is associated with increased lymph node involvement in colorectal cancer

Figure 1 Different immunohistochemical staining patterns of α-catenin in colorectal carcinomas. A: In normal colonic epithelium, α-catenin is predominantly expressed in the cell membrane. B: A medium-powered view of a colonic adenocarcinoma showing membranous expression of α-catenin. C: This case shows both membranous and cytoplasmic expression of α-catenin.

Figure 2 A: Cytoplasmic α-catenin expression and survival with metastasis in univariate (Kaplan-Meier) analysis; B: Combined α-catenin and β-catenin (MI) expression and disease-specific overall survival in Kaplan-Meier analysis.