Ultrastructural changes in hepatocytes after taurine treatment in CCl4 induced liver injury

Figure 1 A: Mild bile duct proliferation (arrow) and microvesicular changes (arrowheads) in Taurine treated animals (HE, × 200); B: Severe macro and microvesicular fatty accumulation (arrowheads) and fibrosis (arrows) in Taurine untreated group (HE, × 50).

Figure 2 Electron micrographs. A: The dilatations in the rER (arrow) and sER (arrowhead), large vacuoles in the hepatocytes (V), a normal nucleus (N) and mitochondria with a prominent edema (small arrow) in CCl₄ plus taurine treated group (× 4000); B: Large dilatations (arrow) and focal breaks (arrowhead) in the rER in CCl₄ plus saline treated group (× 30 000); C: The vacuolizations (V) and myelin figures (m) in the sER, nucleus (N) and mitochondria with prominent edema (arrow) in CCl₄ plus saline treated group (× 4000).

Figure 3 Correlation of histopathologic and ultrastructure scores in CCl₄. A: Plus Taurine treated group (r = 0.931); B: Plus Saline treated group (r = 0.899).