Attenuation of gastric mucosal inflammation induced by aspirin through activation of A2A adenosine receptor in rats

Figure 1 Ulcer length of rats 3 h after the administration of aspirin with or without pretreatment with ATL-146e (2. 5 or 5 μg/kg, ip) (n = 5 each group). ^bP < 0.01 vs aspirin alone treated group.

Figure 2 Effect of ATL-146e on myeloperoxidase concentration in gastric mucosa (n = 5 each group). ^bP < 0.001 vs aspirin alone treated group.

Figure 3 Effect of ATL-146e on increased TNF-α (A) and IL-1β (B) concentration in gastric mucosa induced by aspirin administration (n = 5 each group). ^bP < 0.01, vs aspirin alone treated group.

Figure 4 Effect of 5 μg/kg ATL-146e on gastric acid secretion. Rats were treated with or without 5.0 μg/kg of ATL-146e and killed 3 h later (n = 5 each group). ^aP < 0.05 vs vehicle treated group.

Figure 5 Gastric mucosal concentrations of prostaglandin E2 in control group (vehicle group) and in rats treated with 200 mg/kg aspirin alone or pretreated with 5 μg/kg ATL-146e (n = 5 each group). ^bP < 0.01 vs vehicle treated group. NS: no significant difference between each group.