Effect of the ulcerogenic agents ethanol, acetylsalicylic acid and taurocholate on actin cytoskeleton and cell motility in cultured rat gastric mucosal cells

Figure 1 Effects of different doses of ethanol (ETOH), acetylsalicylic acid (ASA) and taurocholate (TC) on actin filaments of RGM rat gastric surface epithelial cells.

Figure 2 Effects of different doses of ethanol (ETOH), acetylsalicylic acid (ASA) and taurocholate (TC) on the zonula adherens-associated belt-like actin bundles in RGM cells and their modulation by allopurinol (2 mmol/L) treatment. Arrows indicate perturbations in the actin belt organization.

Figure 3 Effects of different doses of ethanol (ETOH), acetylsalicylic acid (ASA) and taurocholate (TC) on vinculin distribution in RGM cells and their modulation by allopurinol (2 mmol/L) treatment. Arrows indicate perturbations in vinculin organization.

Figure 4 Effect of ethanol on cellular migration distance, with and without allopurinol treatment. Ethanol significantly reduced the migrated distance. Allopurinol partially abolished the ethanol promoted inhibition of cell migration.