Relationship between proliferative activity of cancer cells and clinicopathological factors in patients with esophageal squamous cell carcinoma

Figure 1 Ki-67 and cyclin A staining patterns in human normal esophageal mucosa and esophageal SCC. A and E: Negative control in normal esophageal mucosa; B and F: positive nuclear staining in normal esophageal mucosa; C and G: moderately differentiated SCC; D and H: poorly differentiated SCC. Positive nuclear staining was located in base cells in normal mucosa. The diffuse and strong Ki-67 immunostaining in esophageal SCC and the higher SI of the poorly differentiated SCC were found compared with the other carcinomas. Counterstaining with hematoxylin, ×200.