Vascular endothelial growth factor antisense oligodeoxynucleotides with lipiodol in arterial embolization of liver cancer in rats

doi:10.3748/wjg.v10.i6.813

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Mar 15, 2004 (publication date) through Dec 21, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Liver Cancer

World J Gastroenterol. Mar 15, 2004; 10(6): 813-818
Published online Mar 15, 2004. doi: 10.3748/wjg.v10.i6.813

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Figure 1 Pathological changes of tumor tissues 7 d after TAE. A: Control group showing spotty and scattered necrosis. B: LP group showing many patched necrotic zones. C: LP+ODNs group showing big areas of central necrosis. Hematoxylin-eosin ×40.

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Figure 2 RT-PCR analysis of VEGF mRNA level in cancerous and peri-cancerous tissues using G₃PDH as internal control. Control group: 1 tumor, 2 peri-tumor. LP group: 3 tumor, 4 peri-tumor. LP+ODNs group: 5 tumor, 6 peri-tumor, 7 marker.

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Figure 3 Immunohistochemical staining of VEGF in tumor tissues 7 d after TAE, showing strong expression in LP group and low expression in LP+ODNs group. A: Control group, B: LP group, C: LP+ODNs group. SABC ×200.

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Figure 4 Immunohistochemical staining of vWF in tumor tissues 7 d after TAE, showing plenty of microvessels in LP group and a few microvessels in LP+ODNs group. A: Control group, B: LP group, C: LP+ODNs group. SABC×200.

Citation: Wu HP, Feng GS, Liang HM, Zheng CS, Li X. Vascular endothelial growth factor antisense oligodeoxynucleotides with lipiodol in arterial embolization of liver cancer in rats. World J Gastroenterol 2004; 10(6): 813-818
URL: https://www.wjgnet.com/1007-9327/full/v10/i6/813.htm
DOI: https://dx.doi.org/10.3748/wjg.v10.i6.813