Effect of staurosporine on cycle human gastric cancer cell

Figure 1 Inhibition of staurosporine on MGC-803 cell proliferation.

Figure 2 Inhibition of staurosporine on SGC-7901 cell proliferation.

Figure 3 Morphological changes in MGC803 and SGC7901 cells under electron microscope after treatment with ST (200 ng/ml), ×5000. A: MGC803 control cells, B: 200 ng/ml ST-induced MGC803 cells, C: SGC7901 control cells, D: 200 ng/ml ST-induced SGC7901 cells. Note: chromatin condensation and formation of apoptotic bodies.

Figure 4 Effect of ST on cell cycle of human gastric cancer cells. A: Changes of cell cycle in MGC803 cells after ST-treatment for 24h, B: Changes of cell cycle in SGC7901 cells after ST-treatment for 24 h, C: ST-induced apoptosis in MGC-803 cells, D: ST-induced apoptosis in SGC-7901 cells.

Figure 5 Expression of P21 protein in MGC803 and SGC7901 cells after ST-treatment as determined by immunohistochemistry (SP×400). A: MGC803 control cells, B: MGC803 cells treated with 60 ng/ml ST, C: SGC7901 control cells, D: SGC7901 cells treated with 60 ng/ml ST.

Figure 6 Effect of ST treatment on P21^WAF1 mRNA expression in MGC803 cells. M: DNA Marks, 1: control cells, 2: cells treated with 60 ng/ml ST.

Figure 7 Effect of ST treatment on P21^WAF1 mRNA expression in SGC7901 cells. M: DNA Marks, 1: control cells, 2: cells treated with 60 ng/ml ST.