Effects of tegaserod on Fos, substance P and calcitonin gene-related peptide expression induced by colon inflammation in lumbarsacral spinal cord

Figure 1 Sections from the control rats. ×10. A: Fos-IR neurons induced by TNBS administration were observed as black spots in the dorsal horn. Note that most Fos-IR neurons were distributed in the deeper laminae of the dorsal horn. B: SP was mainly distributed in the superficial laminae of the dorsal horn. C: CGRP was primarily localized in the superficial laminae of the dorsal horn.

Figure 2 Sections from rats treated with tegaserod 2 mg/kg·d. ×10. A: After treatment with tegaserod, the number of Fos-IR cells was decreased significantly compared with that of the control group. B: Note that the density of SP in rats treated with tegaserod was decreased significantly compared with that of the control rats. C: The density of CGRP was not different between the treatment group and the control group.