Basic Study
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World J Gastroenterol. Mar 7, 2025; 31(9): 98027
Published online Mar 7, 2025. doi: 10.3748/wjg.v31.i9.98027
Oxidative stress-induced circSOD2 inhibits osteogenesis through sponging miR-29b in metabolic-associated fatty liver disease
Liang-Ping Li, Xiao-Ying Chen, Hong-Bo Liu, Yi Zhu, Min-Jie Xie, Yong-Jian Li, Meng Luo, Mugahed Albahde, Hong-Yu Zhang, Jian-Ying Lou
Liang-Ping Li, Yi Zhu, Min-Jie Xie, Yong-Jian Li, Meng Luo, Mugahed Albahde, Jian-Ying Lou, Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang Province, China
Xiao-Ying Chen, Department of Emergency Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang Province, China
Hong-Bo Liu, Hong-Yu Zhang, Department of General Surgery, The People’s Hospital of Songyang, Lishui 323400, Zhejiang Province, China
Co-first authors: Liang-Ping Li and Xiao-Ying Chen.
Author contributions: Lou JY and Liu HB designed the research study; Li LP, Chen XY and Xie MJ performed the research; Li YJ, Luo M and Zhang HY analyzed the results; Li LP, Zhu Y and Albahde M wrote the manuscript; Lou JY supervised and supported the study; All authors reviewed the manuscript.
Supported by the National and Zhejiang Provincial Administration of Traditional Chinese Medicine Co-construction Project, No. GZY-ZJ-KJ-24080; and the Medical Science and Technology Project of Zhejiang Province, No. 2024XY228.
Institutional review board statement: The study was reviewed and approved by the Ethics Committee of the Second Affiliated Hospital of Zhejiang University School of Medicine, No. IRB-2022-1333.
Institutional animal care and use committee statement: All animal experiments were approved by the Institutional Animal Care and Use Committee of the Second Affiliated Hospital of Zhejiang University School of Medicine, No. AIRB-2022-1453. Healthy 8-week-old male C57BL/J6 mice were purchased from the Laboratory Animal Center of Zhejiang University.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: The data used to support the findings of this study are available from the corresponding author upon reasonable request at loujianying@zju.edu.cn.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jian-Ying Lou, Professor, Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, No.88# Jiefang Road, Shangcheng District, Hangzhou 310009, Zhejiang Province, China. loujianying@zju.edu.cn
Received: June 16, 2024
Revised: November 24, 2024
Accepted: January 23, 2025
Published online: March 7, 2025
Processing time: 247 Days and 6.1 Hours
Core Tip

Core Tip: Emerging evidence indicates that metabolic-associated fatty liver disease (MAFLD) closely associated with oxidative stress, is linked to bone metabolic diseases. Altered expression profiles of liver circular RNAs (circRNAs) have been observed in MAFLD. This study explores the upstream and downstream mechanisms of circSOD2 upregulation in osteogenesis by identifying differentially expressed circRNAs in MAFLD livers. Results demonstrated that circSOD2 upregulation in hepatocytes induced by oxidative stress inhibits osteogenic differentiation of bone marrow mesenchymal stem cells by sponging miR-29b. These findings provide a better understanding of the relationship between MAFLD and osteoporosis from the perspective of circRNAs.