Case Report
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 7, 2025; 31(9): 102059
Published online Mar 7, 2025. doi: 10.3748/wjg.v31.i9.102059
Disseminated liver histoplasmosis in an immunocompetent individual cured by liver transplantation and voriconazole from China: A case report
Chen-Xuan Li, Hao-Dong Chen, Shakoor Kashif, Bin Xie, Jing Luo, Ting Li
Chen-Xuan Li, Hao-Dong Chen, Shakoor Kashif, Bin Xie, Jing Luo, Ting Li, Department of Liver Transplantation, The Second Xiang-ya Hospital, Central South University, Changsha 410011, Hunan Province, China
Chen-Xuan Li, Hao-Dong Chen, Shakoor Kashif, Bin Xie, Jing Luo, Ting Li, Transplant Medical Research Center, The Second Xiang-ya Hospital, Central South University, Changsha 410011, Hunan Province, China
Author contributions: Li T and Li CX conceptualized the study; Xie B and Luo J treated the patient; Li T performed the liver transplantation; Chen HD and Kashif S analyzed the data; Li CX wrote the manuscript; and all authors contributed to the drafting of the manuscript, and read and approved the final version.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ting Li, Associate Chief Physician, Associate Professor, MD, PhD, Department of Liver Transplantation, The Second Xiang-ya Hospital, Central South University, No. 139 Middle Renmin Road, Changsha 410011, Hunan Province, China. liting001@csu.edu.cn
Received: October 7, 2024
Revised: November 29, 2024
Accepted: January 21, 2025
Published online: March 7, 2025
Processing time: 133 Days and 20.3 Hours
Core Tip

Core Tip: Disseminated histoplasmosis in immunocompetent populations presenting solely as liver involvement and progressing to liver failure is rare, and there is no reported case of histoplasmosis cured by liver transplantation. Voriconazole is commonly used for fungal infections, but its experience in treating histoplasmosis is limited. In our report, we detail the case of the world’s first patient to receive liver transplantation surgery for liver failure caused by hepatic histoplasmosis, characterized by a complex and varied progression. After a comprehensive analysis, the patient was ultimately diagnosed and achieved complete recovery with the surgery and voriconazole.