Herbal medicine as a potential treatment for non-alcoholic fatty liver disease

doi:10.3748/wjg.v31.i9.100273

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Mar 7, 2025 (publication date) through Feb 21, 2025

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Mar 7, 2025; 31(9): 100273
Published online Mar 7, 2025. doi: 10.3748/wjg.v31.i9.100273

Herbal medicine as a potential treatment for non-alcoholic fatty liver disease

Wen-Yi Nie, Yang Ye, Hong-Xuan Tong, Jing-Qing Hu

Wen-Yi Nie, Jing-Qing Hu, Department of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun 130117, Jilin Province, China

Yang Ye, Department of Traditional Chinese Medicine, Peking University Third Hospital, Beijing 100191, China

Hong-Xuan Tong, Institute of Basic Theory for Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China

Jing-Qing Hu, China Science and Technology Development Center for Chinese Medicine, Beijing 100027, China

Co-first authors: Wen-Yi Nie and Yang Ye.

Co-corresponding authors: Hong-Xuan Tong and Jing-Qing Hu.

Author contributions: Nie WY and Ye Y contribute equally to this study as co-first authors; Tong HX and Hu JQ contribute equally to this study as co-corresponding authors; Nie WY and Ye Y wrote the first draft of the manuscript; Ye Y and Tong HX contributed to review and editing; Tong HX and Hu JQ conceived, reviewed, and revised this paper.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Hong-Xuan Tong, PhD, Research Assistant, Institute of Basic Theory for Chinese Medicine, China Academy of Chinese Medical Sciences, No. 16 Nanxiao Street, Dongcheng District, Beijing 100700, China. thongxuan1@163.com

Received: August 12, 2024
Revised: January 6, 2025
Accepted: January 18, 2025
Published online: March 7, 2025
Processing time: 190 Days and 5.1 Hours

Core Tip

Core Tip: Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive liver fat accumulation linked to metabolic syndrome. The progression from steatosis to steatohepatitis involves inflammation, injury, and fibrosis. Current treatments focus on lifestyle changes and metabolic management, highlighting the need for novel therapies. Niu et al showed promising results for the Fanlian Huazhuo Formula, a traditional Chinese medicine used for treating NAFLD. This study reviews the strengths, limitations, and directions of future research.