Letter to the Editor
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 28, 2025; 31(8): 101357
Published online Feb 28, 2025. doi: 10.3748/wjg.v31.i8.101357
Irritable bowel syndrome remains a complex disorder of gut-brain interaction: Too many actors on stage
Raffaele Pellegrino, Antonietta Gerarda Gravina
Raffaele Pellegrino, Antonietta Gerarda Gravina, Division of Hepatogastroenterology, Department of Precision Medicine, University of Campania Luigi Vanvitelli, Naples 80138, Italy
Author contributions: Pellegrino R and Gravina AG reviewed the literature, wrote the initial manuscript, conceptualized the figure, conceptualized the structure of the text, and critically revised the manuscript for important intellectual content; All authors read and approved the final version of the manuscript to be published.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Raffaele Pellegrino, MD, Division of Hepatogastroenterology, Department of Precision Medicine, University of Campania Luigi Vanvitelli, Via L De Crecchio, Naples 80138, Italy. raffaele.pellegrino@unicampania.it
Received: September 11, 2024
Revised: December 29, 2024
Accepted: January 6, 2025
Published online: February 28, 2025
Processing time: 133 Days and 15.2 Hours
Core Tip

Core Tip: This letter highlights the complex interplay among the neuroendocrine axis, gut microbiota, and inflammatory response in irritable bowel syndrome (IBS). By adopting a multiparametric approach, the findings proposed by the commented article suggest that IBS involves both gastrointestinal and neuroendocrine factors, supporting the biopsychosocial model for understanding and managing functional gastrointestinal disorders.