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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 28, 2025; 31(8): 100146
Published online Feb 28, 2025. doi: 10.3748/wjg.v31.i8.100146
Published online Feb 28, 2025. doi: 10.3748/wjg.v31.i8.100146
Multiple primary cancers with gastrointestinal malignant tumors as the first manifestation: Three case reports and review of literature
Xin-Ran Bi, Shuang-Yan Zhao, Yu-Qi Ma, The First Clinical Medical College of Gansu University of Traditional Chinese Medicine, Lanzhou 730000, Gansu Province, China
Xin-Ran Bi, Shuang-Yan Zhao, Xiao-Yu Duan, Ting-Ting Hu, Hong-Yi Cai, Department of Radiotherapy Center, Gansu Provincial Hospital, Lanzhou 730000, Gansu Province, China
Yu-Qi Ma, Department of Gastrointestinal Surgery, Gansu Provincial Hospital, Lanzhou 730000, Gansu Province, China
Lian-Zhu Bi, Department of Neurology, Hospital of Fengnan District, Tangshan 063300, Hebei Province, China
Co-first authors: Xin-Ran Bi and Shuang-Yan Zhao.
Author contributions: Bi XR was responsible for article writing; Zhao SY and Ma YQ were responsible for figures preparation; Duan XY and Hu TT conducted continuous follow-up of the patients; Bi LZ provided guidance for the writing of the paper; Cai HY completed the article revising. All authors have read and approved the final manuscript. Bi XR and Zhao SY are co-first authors of this paper.
Supported by Gansu Provincial Natural Science Foundation, No. 21JR1RA010; and the In-Hospital Research Fund of Gansu Provincial Hospital, No. 23GSSYD-5.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare no conflicts of interest. The funders played an important role in the writing of the manuscript.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hong-Yi Cai, Doctor, Chief Physician, Professor, Department of Radiotherapy Center, Gansu Provincial Hospital, No. 204 East Gang West Road, Lanzhou 730000, Gansu Province, China. gschy333@163.com
Received: August 8, 2024
Revised: December 3, 2024
Accepted: January 13, 2025
Published online: February 28, 2025
Processing time: 167 Days and 14 Hours
Revised: December 3, 2024
Accepted: January 13, 2025
Published online: February 28, 2025
Processing time: 167 Days and 14 Hours
Core Tip
Core Tip: Multiple primary cancer (MPC) refers to the presence of two or more distinct primary malignant tumors that arise in either the same organ or multiple separate organs and tissues within a single patient. This article offers a detailing three cases of gastrointestinal malignancies with MPCs. It features a thorough presentation of endoscopic, tomographic, and biopsy images, including both macroscopic and microscopic views. Besides, the article highlights the importance of comprehensive management for patients with MPCs, aiming to raise clinicians' awareness and improve patient outcomes.