Basic Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 28, 2025; 31(8): 100069
Published online Feb 28, 2025. doi: 10.3748/wjg.v31.i8.100069
Glial cell line-derived neurotrophic factor improves impaired colonic motility in experimental colitis mice through connexin 43
Wei Yang, Rui Liu, Feng Xu
Wei Yang, Feng Xu, Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China
Rui Liu, Medical School, Xiangyang Vocational and Technical College, Xiangyang 441021, Hubei Province, China
Author contributions: Yang W contributed to study concept and design and manuscript drafting; Yang W and Liu R contributed to data analysis and interpretation; Xu F contributed to critical revision of the manuscript for important intellectual content; Liu R contributed to statistical analysis; Yang W, Liu R and Xu F contributed to study supervision; All authors have read and approved the manuscript.
Institutional review board statement: This study does not involve any human experiments.
Institutional animal care and use committee statement: Prior to this study, approval for all experimental procedures was obtained from the Institutional Animal Care and Use Committee (approval No. 2022175). Throughout the experiment, every effort was made to minimize the distress of the mice.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: The data supporting the findings of this study are available from the corresponding author upon request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Feng Xu, MD, Chief Doctor, Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road, Erqi District, Zhengzhou 450052, Henan Province, China. fengx2024@126.com
Received: August 6, 2024
Revised: December 6, 2024
Accepted: December 25, 2024
Published online: February 28, 2025
Processing time: 169 Days and 17.4 Hours
Core Tip

Core Tip: The study investigated the therapeutic potential of glial cell line-derived neurotrophic factor (GDNF) in ameliorating impaired colonic motility in a dextran sodium sulfate-induced ulcerative colitis mouse model. The findings revealed that GDNF partially enhanced colonic transit and alleviated intestinal inflammation, with its effects reliant on connexin 43 activity. The findings identified GDNF as a promising candidate for treating abnormal colonic motility in ulcerative colitis patients, highlighting the significance of connexin 43 in its therapeutic mechanism.