Basic Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 21, 2025; 31(7): 98852
Published online Feb 21, 2025. doi: 10.3748/wjg.v31.i7.98852
Inhibition of metabotropic glutamate receptor-5 alleviates hepatic steatosis by enhancing autophagy via activation of the AMPK signaling pathway
Min Tao, Li-Li Zhang, Guang-Hong Zhou, Cong Wang, Xie Luo
Min Tao, Li-Li Zhang, Guang-Hong Zhou, Cong Wang, Xie Luo, Department of Endocrinology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China
Author contributions: Tao M performed the majority of the experiments and contributed to the analysis of the data and the drafting of the manuscript; Zhou GH contributed to the analysis of the data; Zhang LL and Wang C revised and approved the final version of the manuscript; Luo X contributed to the study design, the drafting of the manuscript, and critical discussion and approved the final version of the manuscript.
Supported by National Natural Science Foundation of China, No. 81800771 and No. 81300702.
Institutional review board statement: The study was reviewed and approved by the Second Affiliated Hospital of Chongqing Medical University Institutional Review Board [Approval No. 2018(51)].
Institutional animal care and use committee statement: This study protocol was reviewed and approved by the Animal Care and Use Ethics Committee of Chongqing Medical University, Chongqing, China (protocol approval number: IACUC-CQMU-2024-0085).
Conflict-of-interest statement: All the authors have no conflicts of interest related to the manuscript.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xie Luo, Doctor, MD, PhD, Department of Endocrinology, The Second Affiliated Hospital, Chongqing Medical University, No. 74 Linjiang Road, Yuzhong District, Chongqing 400010, China. 304408@hospital.cqmu.edu.cn
Received: July 7, 2024
Revised: December 8, 2024
Accepted: December 26, 2024
Published online: February 21, 2025
Processing time: 196 Days and 15.5 Hours
Core Tip

Core Tip: The present work showed that inhibition of metabotropic glutamate receptor 5 can activate the AMPK signaling pathway, promoting the entry of transcription factor EB into the nucleus and enhancing autophagy, which will ameliorate hepatocyte steatosis.