Effectiveness of biologics for endoscopic healing in patients with isolated proximal small bowel Crohn’s disease

doi:10.3748/wjg.v31.i7.98448

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Study

World J Gastroenterol. Feb 21, 2025; 31(7): 98448
Published online Feb 21, 2025. doi: 10.3748/wjg.v31.i7.98448

Effectiveness of biologics for endoscopic healing in patients with isolated proximal small bowel Crohn’s disease

Zi-Cheng Huang, Bi-Yao Wang, Bo Peng, Zhong-Cheng Liu, Hui-Xian Lin, Qing-Fan Yang, Jian Tang, Kang Chao, Miao Li, Xiang Gao, Qin Guo

Zi-Cheng Huang, Bi-Yao Wang, Bo Peng, Hui-Xian Lin, Qing-Fan Yang, Jian Tang, Kang Chao, Miao Li, Xiang Gao, Qin Guo, Department of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510000, Guangdong Province, China

Zi-Cheng Huang, Bo Peng, Zhong-Cheng Liu, Qing-Fan Yang, Jian Tang, Kang Chao, Miao Li, Xiang Gao, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510000, Guangdong Province, China

Zi-Cheng Huang, Bo Peng, Qing-Fan Yang, Jian Tang, Kang Chao, Miao Li, Xiang Gao, Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510000, Guangdong Province, China

Bo Peng, Zhong-Cheng Liu, Miao Li, Qin Guo, Department of Small Bowel Endoscopy, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510000, Guangdong Province, China

Co-first authors: Zi-Cheng Huang and Bi-Yao Wang.

Author contributions: Huang ZC and Wang BY were involved in the study concept and design, data acquisition, quality control of the data, data analysis and interpretation, statistical analysis, manuscript preparation, editing, and review; Peng B, Liu ZC, Lin HX, Yang QF, Tang J, Chao K, Li M were involved in data acquisition, and quality control of data; Gao X and Guo Q were involved in study concept and design, critical revision of the manuscript, and study supervision; All authors have read and approved the final manuscript.

Supported by the Program of Guangdong Provincial Clinical Research Center for Digestive Diseases, No. 2020B1111170004.

Institutional review board statement: The study was reviewed and approved by the Sixth Affiliated Hospital of Sun Yat-sen University Institutional Review Board (Approval No. 2023ZSLYEC-609).

Informed consent statement: Informed consent from patients was waived because the study was retrospective and all patient data were fully de-identified.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Data sharing statement: The data used and/or analyzed during the current study are available from the corresponding author on reasonable request at guoq83@mail.sysu.edu.cn.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Qin Guo, PhD, Professor, Department of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, No. 26 Erheng Road, Yuancun, Tianhe District, Guangzhou 510000, Guangdong Province, China. guoq83@mail.sysu.edu.cn

Received: June 29, 2024
Revised: November 30, 2024
Accepted: January 2, 2025
Published online: February 21, 2025
Processing time: 204 Days and 14.2 Hours

Core Tip

Core Tip: Endoscopic healing (EH) is a key treatment target for Crohn’s disease (CD), but limited data are available on isolated proximal small bowel (SB) disease. This retrospective study analyzed the data of patients with isolated proximal SB CD identified through balloon-assisted enteroscopy. We aimed to evaluate the effectiveness of biologics for EH in patients with jejunal and proximal ileal CD at 1 year. The results showed that 20.9% of patients achieved complete EH after 1-year biologic therapy. Failure to achieve complete EH was significantly associated with stricturing or penetrating disease, prior exposure to biologics, and moderate-to-severe endoscopic disease.