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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 21, 2025; 31(7): 97599
Published online Feb 21, 2025. doi: 10.3748/wjg.v31.i7.97599
Published online Feb 21, 2025. doi: 10.3748/wjg.v31.i7.97599
Protective effects of autologous bone marrow-derived mesenchymal stem cell transplantation on acute radioactive enteritis in Beagle dogs
Guang-Chen Sun, College of Medicine and Biological Information Engineering, Northeastern University, Shenyang 110000, Liaoning Province, China
Guang-Chen Sun, Ruo-Nan Chai, Department of Respiratory Medicine, General Hospital of Northern Theater Command, Shenyang 110000, Liaoning Province, China
Wen-Da Xu, Hui Yao, Jiang Chen, Department of Gastroenterology, General Hospital of Northern Theater Command, Shenyang 110000, Liaoning Province, China
Co-corresponding authors: Jiang Chen and Ruo-Nan Chai.
Author contributions: Sun GC, Chen J, and Xu WD conceptualized and designed the research; Sun GC and Yao H isolated the sample cells and performed cell culture and identification; Chen J and Xu WD established a disease model and evaluated relevant monitoring indicators; Chen J and Chai RN performed data analysis; Sun GC, Chen J, and Chai RN wrote the paper; all the authors have read and approved the final manuscript. Chen J applied for and obtained the funds for this research project. He conceptualized, designed, and supervised the whole process of the project. Chai RN is instrumental and responsible for data re-analysis and re-interpretation, figure plotting, comprehensive literature search, and preparation and revision of the manuscript. Both authors have made crucial and indispensable contributions towards the completion of the project and thus qualified as the co-corresponding authors of the paper.
Supported by People's Livelihood Science and Technology Plan Joint Project of Liaoning Province, No. 2021JH2/10300083.
Institutional animal care and use committee statement: The animal experiments were approved by the Animal Medical Research Ethics Committee of General Hospital of Northern Theater Command of PLA (Protocol No. 2023-15; April 14, 2023).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: The datasets involved in the current study are available from the corresponding author at matrix44@126.com on reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jiang Chen, PhD, Chief Physician, Professor, Department of Gas
Received: June 4, 2024
Revised: November 25, 2024
Accepted: December 18, 2024
Published online: February 21, 2025
Processing time: 230 Days and 3.9 Hours
Revised: November 25, 2024
Accepted: December 18, 2024
Published online: February 21, 2025
Processing time: 230 Days and 3.9 Hours
Core Tip
Core Tip: Mesenchymal stem cell transplantation has a therapeutic role in intestinal radiation injury, but the exact mechanism is unknown. In the present study, we explored the therapeutic role of autologous bone marrow-derived mesenchymal stem cells (ABMSCs) and their possible mechanisms in a Beagle model of radioactive intestinal injury. Our experimental results suggest that ABMSC transplantation has a protective effect against acute radiation enteritis in Beagle dogs and that interleukin-10 and monocyte chemotactic protein-1 may play an important role in the treatment of ABMSCs.