Basic Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 21, 2025; 31(7): 96459
Published online Feb 21, 2025. doi: 10.3748/wjg.v31.i7.96459
Mesalazine alleviated the symptoms of spontaneous colitis in interleukin-10 knockout mice by regulating the STAT3/NF-κB signaling pathway
Qian Chen, Ya-Li Zhang, Yong-Quan Shi, Lie Zheng
Qian Chen, Ya-Li Zhang, Institute of Digestive Disease, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
Yong-Quan Shi, Department of Gastroenterology, Xijing Hospital affiliated to Air Force Medical University, Xi’an 710032, Shaanxi Province, China
Lie Zheng, Department of Gastroenterology, Traditional Chinese Medicine Hospital of Shaanxi Province, Xi’an 710003, Shaanxi Province, China
Co-first authors: Qian Chen and Ya-Li Zhang.
Author contributions: Chen Q and Zhang YL performed the major experiments, they contributed equally as co-first authors; Shi YQ and Zheng L performed the experiments and analyzed the data; Chen Q, Zhang YL, and Zheng L designed and coordinated the study; and all authors approved the final manuscript.
Supported by Xi’an Science and Technology Plan Project, No. 23YXYJ0162; Shaanxi Province Traditional Chinese Medicine Research and Innovation Talent Plan Project, No. TZKN-CXRC-16; Project of Shaanxi Administration of Traditional Chinese Medicine, No. SZY-KJCYC-2025-JC-010; Shaanxi Province Key Research and Development Plan Project-Social Development Field, No. S2025-YF-YBSF-0391; and the Science and Technology Innovation Cultivation Program of Longhua Hospital affiliated to Shanghai University of Chinese Medicine, No. YD202220.
Institutional animal care and use committee statement: The study was reviewed and approved by the Animal Ethics Committee of the Shanghai University of Traditional Chinese Medicine (No. PZSHUTCM191108004).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lie Zheng, PhD, Department of Gastroenterology, Traditional Chinese Medicine Hospital of Shaanxi Province, No. 4 Xihuamen, Lianhu District, Xi’an 710003, Shaanxi Province, China. 492688049@qq.com
Received: May 7, 2024
Revised: December 1, 2024
Accepted: December 27, 2024
Published online: February 21, 2025
Processing time: 257 Days and 19 Hours
Core Tip

Core Tip: Long-term and persistent excessive endoplasmic reticulum stress in IL-10-/- mice intestinal epithelial cells destroy the intestinal mucosal barrier and activates the signal transducer and activator of transcription 3/nuclear factor kappa B pathway, leading to the spontaneous generation of ulcerative colitis. Mesalazine could alleviate the symptoms of colitis in IL-10-/- mice, regulate endoplasmic reticulum stress and down-regulate the signal transducer and activator of transcription 3/nuclear factor kappa B pathway.