Evaluating the scope of human leukocyte antigen polymorphisms influencing hepatitis B virus-related liver cancer and cirrhosis through multi-clustering analysis

doi:10.3748/wjg.v31.i7.102632

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Feb 21, 2025; 31(7): 102632
Published online Feb 21, 2025. doi: 10.3748/wjg.v31.i7.102632

Evaluating the scope of human leukocyte antigen polymorphisms influencing hepatitis B virus-related liver cancer and cirrhosis through multi-clustering analysis

Shi Li, Yue Xi, Xue-Ying Dong, Wen-Bin Yuan, Jing-Feng Tang, Ce-Fan Zhou

Shi Li, Yue Xi, Xue-Ying Dong, Wen-Bin Yuan, Jing-Feng Tang, Ce-Fan Zhou, School of Life and Health Sciences, Institute of Biomedical Research, National “111” Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, Wuhan 430068, Hubei Province, China

Author contributions: Li S prepared the original draft; Zhou CF contributed to the conceptualization, writing, review and editing of the manuscript; Li S, Xi Y, and Zhou CF collaboratively drafted the manuscript; Dong XY, Yuan WB, and Tang JF provided some valuable opinion; and all authors have reviewed and approved the final version of the manuscript.

Supported by National Natural Science Foundation of China, No. 32270768, No. 82273970, No. 32070726, and No. 82370715; National Key R&D Program of China, No. 2023YFC2507904; and the Innovation Group Project of Hubei Province, No. 2023AFA026.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Ce-Fan Zhou, School of Life and Health Sciences, Institute of Biomedical Research, National “111” Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, No. 28 Nanli Road, Wuhan 430068, Hubei Province, China. cefan@hbut.edu.cn

Received: October 24, 2024
Revised: November 21, 2024
Accepted: December 18, 2024
Published online: February 21, 2025
Processing time: 88 Days and 12.1 Hours

Core Tip

Core Tip: A significant correlation has been identified between polymorphisms of human leukocyte antigen-DP-DQ and the risk of liver cirrhosis and hepatocellular carcinoma linked to hepatitis B virus infection. In this article, we aim to highlight this study has the potential to transform personalized medical treatments and prevention strategies through the identification of key molecular markers. Additionally, incorporating other upregulated genes related to hepatitis B virus infection could uncover additional genetic markers, greatly enhancing the management and treatment of liver disease.