Letter to the Editor
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 21, 2025; 31(7): 100044
Published online Feb 21, 2025. doi: 10.3748/wjg.v31.i7.100044
Helicobacter pylori infection and gastric microbiota: Insights into gastric and duodenal ulcer development
Yan Pan, Fu-Yong Jiao
Yan Pan, Department of Pediatric, The First Affiliated Hospital of Yangtze University, Jingzhou 434000, Hubei Province, China
Fu-Yong Jiao, Shaanxi Kawasaki Disease Diagnosis and Treatment Center, Children’s Hospital, Shaanxi Provincial People’s Hospital of Xi’an, Jiaotong Univeristy, Xi’an 710000, Shaanxi Province, China
Author contributions: Pan Y designed the research study, performed the research, contributed new reagents and analytic tools, analyzed the data, wrote the manuscript, read and approve the final manuscript; Jiao FY designed the research study; and all authors thoroughly reviewed and endorsed the final manuscript.
Conflict-of-interest statement: All authors declare that they have no conflicts of interest.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Fu-Yong Jiao, PhD, Shaanxi Kawasaki Disease Diagnosis and Treatment Center, Children’s Hospital, Shaanxi Provincial People’s Hospital of Xi’an, Jiaotong Univeristy, No. 256 Youyi West Road, Beilin District, Xi’an 710000, Shaanxi Province, China. 3105089948@qq.com
Received: August 6, 2024
Revised: December 11, 2024
Accepted: December 20, 2024
Published online: February 21, 2025
Processing time: 167 Days and 5.9 Hours
Core Tip

Core Tip: In Jin et al’s study, Helicobacter pylori (H. pylori) infection significantly alters the gastric microbiota in patients with gastric ulcers, reducing microbial diversity and promoting specific metabolic pathways. This research highlights the importance of understanding H. pylori’s role in gastric ulcer development and suggests that H. pylori is one of several factors influencing duodenal ulcers. Future studies should focus on exploring the complex interactions between H. pylori and the microbiota to develop targeted prevention and treatment strategies for ulcerative diseases.