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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 28, 2025; 31(4): 99397
Published online Jan 28, 2025. doi: 10.3748/wjg.v31.i4.99397
Published online Jan 28, 2025. doi: 10.3748/wjg.v31.i4.99397
Unlocking the potential of Calculus bovis: A breakthrough in liver cancer treatment via Wnt/β-catenin pathway modulation
Farouk Benmediouni, Department of Internal Medicine, Mixed Hospital of Laghouat, Laghouat Faculty of Medicine, Amar Telidji University, Laghouat 03000, Algeria
Author contributions: Benmediouni F participated in the writing, discussion, editing and literature review of this paper and designed the overall concept and outline of the manuscript.
Conflict-of-interest statement: The author reports no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Farouk Benmediouni, Assistant Professor, Chief Physician, MD, Department of Internal Medicine, Mixed Hospital of Laghouat, Laghouat Faculty of Medicine, Amar Telidji University, Elwiam District, Laghouat 03000, Algeria. fbenmediouni@yahoo.fr
Received: July 21, 2024
Revised: November 14, 2024
Accepted: December 2, 2024
Published online: January 28, 2025
Processing time: 161 Days and 13.8 Hours
Revised: November 14, 2024
Accepted: December 2, 2024
Published online: January 28, 2025
Processing time: 161 Days and 13.8 Hours
Core Tip
Core Tip: This article discusses the significant findings of Huang et al, who demonstrated that Calculus bovis, a traditional Chinese medicine, exhibits potent anti-liver cancer effects. The study revealed that Calculus bovis effectively inhibits M2 tumor-associated macrophage polarization by modulating the Wnt/β-catenin pathway, leading to reduced tumor growth and improved tumor regression in vivo. These insights underscore the potential of integrating traditional Chinese medicinal approaches with modern therapeutic strategies to develop novel, multi-targeted treatments for liver cancer, addressing a critical need in oncology.