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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 28, 2025; 31(4): 102135
Published online Jan 28, 2025. doi: 10.3748/wjg.v31.i4.102135
Published online Jan 28, 2025. doi: 10.3748/wjg.v31.i4.102135
Mild liver injury following withdrawal of long-term prednisone therapy: A case report
Jing-Wen Zhu, Jun Yan, Zhi-Han Zhang, Tian-Qi Wang, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, Henan Province, China
Co-first authors: Jing-Wen Zhu and Jun Yan.
Author contributions: Zhu JW and Yan J are listed as co-first authors; Zhu JW, Yan J, and Zhang ZH contributed to data collection and literature search; Wang TQ contributed to data collection, literature search, and drafting and revision of the manuscript; all authors have read and approved the final manuscript.
Informed consent statement: Informed written consent was obtained from the patient for the publication of this report.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Tian-Qi Wang, PhD, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Zhengzhou University, No. 100 Kexue Avenue, Zhengzhou 450001, Henan Province, China. tianqi@zzu.edu.cn
Received: October 9, 2024
Revised: December 2, 2024
Accepted: December 17, 2024
Published online: January 28, 2025
Processing time: 81 Days and 18 Hours
Revised: December 2, 2024
Accepted: December 17, 2024
Published online: January 28, 2025
Processing time: 81 Days and 18 Hours
Core Tip
Core Tip: This paper describes a rare case of mild hypertransaminasemia occurring following withdrawal of long-term prednisone therapy, a condition that is potentially underestimated and easily ignored. The presented case suggests that hypertransaminasemia caused by glucocorticoid withdrawal may have different features from hypertransaminasemia due to primary Addison's disease; the severity of adrenal insufficiency may be associated with the development of elevated transminases and their levels; and glycyrrhizin may be an option for patients with mild adrenal insufficiency due to glucocorticoid withdrawal who have planned to discontinue this hormonal therapy.