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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 21, 2025; 31(3): 99358
Published online Jan 21, 2025. doi: 10.3748/wjg.v31.i3.99358
Published online Jan 21, 2025. doi: 10.3748/wjg.v31.i3.99358
Unraveling the therapeutic potential of Calculus Bovis in liver cancer: A novel step for targeted cancer treatment
Xing-Yu Chen, Xiang Lan, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
Author contributions: Chen XY is responsible for the writing of the article; Lan X provided guidance throughout the writing process of the article.
Conflict-of-interest statement: The authors of this editorial declare that they have no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiang Lan, MD, PhD, Professor, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuan
Received: July 20, 2024
Revised: November 11, 2024
Accepted: November 22, 2024
Published online: January 21, 2025
Processing time: 152 Days and 12.2 Hours
Revised: November 11, 2024
Accepted: November 22, 2024
Published online: January 21, 2025
Processing time: 152 Days and 12.2 Hours
Core Tip
Core Tip: Calculus Bovis (CB), a valuable herb in traditional Chinese medicine, has shown definite anti-liver cancer effects in vivo. Analyses of the composition of CB and the use of network pharmacology for target prediction revealed that CB has anti-liver cancer effects by affecting immune-related pathways in the tumor microenvironment. Transcriptome sequencing demonstrated that the regulation of the M2-type tumor-associated macrophage (TAM) polarization is responsible for the effects of CB. In vitro studies revealed that modulating the Wnt/β-catenin pathway is a crucial mechanism by which CB regulates M2 polarization of TAMs. The present study provides evidence for the development of liver cancer therapeutics.