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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 21, 2025; 31(3): 102283
Published online Jan 21, 2025. doi: 10.3748/wjg.v31.i3.102283
Published online Jan 21, 2025. doi: 10.3748/wjg.v31.i3.102283
Computed tomography enterography-based radiomics for assessing mucosal healing in patients with small bowel Crohn's disease
Hao Ding, Yuan-Yuan Fang, Chen-Yu Zhang, Jing Hu, Wei Han, Qiao Mei, Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China
Wen-Jie Fan, Department of Radiation Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China
Shao-Fei Wang, Department of Gastroenterology, Suzhou First People's Hospital, Suzhou 234099, Anhui Province, China
Co-first authors: Hao Ding and Yuan-Yuan Fang.
Co-corresponding authors: Wei Han and Qiao Mei.
Author contributions: Mei Q and Han W were responsible for the conception and design of the work; Ding H, Fang YY, Fan WJ, Zhang CY, Wang SF, and Hu J contributed to the acquisition, analysis, and interpretation of data for the work; Ding H and Fang YY wrote the manuscript; Mei Q reviewed and edited the manuscript; all authors participated in the interpretation of the studies and analysis of the data; all authors read and approved the final manuscript.
Supported by Natural Science Foundation of Anhui Medical University, No. 2023xkj130.
Institutional review board statement: The study was conducted in accordance with the 1964 Helsinki declaration and its later amendments and approved by the Clinical Medical Research Ethics Committee of the First Affiliated Hospital of Anhui Medical University (ETIC 5101116).
Informed consent statement: This study retrospectively collected clinical data of patients with small Crohn’s disease, and these data were analyzed anonymously. The informed consent waiver was granted by the Institutional Review Board.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qiao Mei, MD, PhD, Professor, Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Hefei 230022, Anhui Province, China. meiqiaomq@aliyun.com
Received: October 13, 2024
Revised: November 19, 2024
Accepted: December 3, 2024
Published online: January 21, 2025
Processing time: 67 Days and 11.4 Hours
Revised: November 19, 2024
Accepted: December 3, 2024
Published online: January 21, 2025
Processing time: 67 Days and 11.4 Hours
Core Tip
Core Tip: Mucosal healing (MH) of small bowel (SB) in Crohn's disease (CD) is difficult to assess due to its limited accessibility through conventional endoscopic methods. Radiomics is a novel tool and has a good performance in disease diagnosis and efficacy evaluation. Here, we developed a computed tomography enterography-based radiomic-clinical nomogram to assess MH for SBCD patients with an area under the receiver operating characteristic curve of 0.961 in the training cohort and 0.958 in the test cohort, highlighting the potential of radiomics as an imaging biomarker and a noninvasive alternative to enteroscopy for MH assessment in SBCD.