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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 14, 2025; 31(22): 105157
Published online Jun 14, 2025. doi: 10.3748/wjg.v31.i22.105157
Published online Jun 14, 2025. doi: 10.3748/wjg.v31.i22.105157
N6-methyladenosine reader IGF2BP2 regulates NIPSNAP1-mediated mitophagy and mitochondrial dynamics to alleviate hepatic ischemia-reperfusion injury
Shan-Shan Guo, Yan Hu, Department of Pharmacy, The Second Affiliated Hospital of Dalian Medical University, Dalian 116044, Liaoning Province, China
Yan Zhao, Xin-Ying Wang, Qin-Rong Luan, Zhe-Cheng Wang, Ji-Hong Yao, Department of Pharmacology, Dalian Medical University, Dalian 116044, Liaoning Province, China
Xu-Zi Zhao, Pei-Yan Zhong, Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian 116044, Liaoning Province, China
Co-first authors: Shan-Shan Guo and Yan Zhao.
Co-corresponding authors: Zhe-Cheng Wang and Ji-Hong Yao.
Author contributions: Guo SS and Zhao Y contributed equally to this article, they are the co-first authors of this manuscript; Guo SS, Wang ZC, and Yao JH designed the study; Guo SS, Hu Y, Zhao Y, and Zhong PY performed the experiments; Guo SS, Wang XY, Zhao XZ, and Luan QR analyzed the data; Guo SS and Wang ZC drafted the manuscript; Wang ZC and Yao JH contributed equally to this article, they are the co-corresponding authors of this manuscript; and all authors thoroughly reviewed and endorsed the final manuscript.
Supported by the National Natural Science Foundation of China, No. 82200658.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of Dalian Medical University, approval No. AEE20004.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: All the data obtained in the current study are available from the corresponding authors upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhe-Cheng Wang, PhD, Department of Pharmacology, Dalian Medical University, No. 9 West Section, Shunnan Road, Shunkou District, Dalian 116044, Liaoning Province, China. wangzc03@dmu.edu.cn
Received: January 14, 2025
Revised: April 20, 2025
Accepted: May 26, 2025
Published online: June 14, 2025
Processing time: 150 Days and 0.2 Hours
Revised: April 20, 2025
Accepted: May 26, 2025
Published online: June 14, 2025
Processing time: 150 Days and 0.2 Hours
Core Tip
Core Tip: We confirmed the effect of 4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (NIPSNAP1) as a new target that controls mitophagy and mitochondrial dynamics in hepatic ischemia-reperfusion. Knockdown of NIPSNAP1 impaired mitophagy and disrupted mitochondrial dynamics, as evidenced by increased mitochondrial fission and reduced fusion. Further studies revealed that interacted with insulin-like growing factor 2 acts as an n6-methyladenosine reader to bind NIPSNAP1 mRNA and enhance its stability, thereby regulating NIPSNAP1 expression. These results suggest that the interacted with insulin-like growing factor 2/NIPSNAP1 axis may be a promising target for hepatic ischemia-reperfusion.