Retrospective Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 7, 2025; 31(21): 107029
Published online Jun 7, 2025. doi: 10.3748/wjg.v31.i21.107029
Evaluating log odds of positive lymph nodes as a prognostic tool in differentiated gastric cancer: A retrospective study
Ming-Cong Deng, Ken Chen, Qi-Mei Bao, Yi-Xing Huang, Chun-Kai Zhang, Yu-Ke Zhong, Han-Yi He, Dan Zu, Chen Liang, Hai-Dong Liu, Yang-Chan Hu, Guo-Xia Liu, Yan-Hua He, Wei-Xing Wu, Jing-Nan Zhou, Yao-Shu Teng, Ji Jing, Yin Shi, Clive Yik-Sham Chung, Chen-Huan Yu, Yi-An Du, Zu Ye, Xiang-Dong Cheng
Ming-Cong Deng, Ken Chen, Qi-Mei Bao, Yi-Xing Huang, Chun-Kai Zhang, Yu-Ke Zhong, Han-Yi He, Dan Zu, Chen Liang, Hai-Dong Liu, Yang-Chan Hu, Guo-Xia Liu, Yan-Hua He, Wei-Xing Wu, Jing-Nan Zhou, Ji Jing, Chen-Huan Yu, Yi-An Du, Zu Ye, Xiang-Dong Cheng, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine, Chinese Academy of Sciences, Hangzhou 310022, Zhejiang Province, China
Ming-Cong Deng, Hangzhou Medical College, Hangzhou 310013, Zhejiang Province, China
Ken Chen, The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang Province, China
Ken Chen, Yi-Xing Huang, Yao-Shu Teng, Department of Otorhinolaryngology, Affiliated Hangzhou First People’s Hospital, School of Medicine, Westlake University, Hangzhou 310006, Zhejiang Province, China
Yi-Xing Huang, Yin Shi, School of Medicine, Zhejiang University, Hangzhou 310058, Zhejiang Province, China,
Dan Zu, Guo-Xia Liu, School of Life Sciences, Tianjin University, Tianjin 300100, China
Hai-Dong Liu, Yi-An Du, Zu Ye, Xiang-Dong Cheng, Zhejiang Provincial Research Center for Upper Gastrointestinal Tract Cancer, Zhejiang Cancer Hospital, Hangzhou 310022, Zhejiang Province, China
Hai-Dong Liu, Yi-An Du, Zu Ye, Xiang-Dong Cheng, Key Laboratory of Prevention, Diagnosis and Therapy of Upper Gastrointestinal Cancer of Zhejiang Province, Hangzhou 310022, Zhejiang Province, China
Clive Yik-Sham Chung, School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
Clive Yik-Sham Chung, Department of Pathology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
Co-corresponding authors: Xiang-Dong Cheng, Zu Ye, Yi-An Du and Chen-Huan Yu.
Author contributions: Deng MC and Chen K wrote the original draft; Deng MC, Chen K, Huang YX, Zhang CK, Zhong YK, Bao QM, Zu D, Liang C, Wu WX, Ten YS, and Liu HD carried out normal analyses, data collation; Deng MC, Chen K, He HY, Hu YC, Liu GX, He YH, Zhou JN, and Jing J made a survey of the manuscript, examining the methodology; Deng MC, Chen K, Shi Y, Chung CYS, Yu CH, Du YA, Ye Z, and Cheng XD conceived and wrote, reviewed, and edited the manuscript; Ye Z and Cheng XD contributed equally to this article, they are the co-corresponding authors of this manuscript; and all authors thoroughly reviewed and endorsed the final manuscript.
Supported by the National Natural Science Foundation of China, No. 82473195 and No. 32370797; the Natural Science Foundation of Zhejiang Province, No. LTGY23H160018; the Zhejiang Medical and Health Science and Technology Program, No. 2024KY789 and No. 2023KY615; the National Research Center for Translational Medicine at Shanghai Program, No. NRCTM(SH)-2025-07; the Beijing Science and Technology Innovation Medical Development Foundation, No. KC2023-JX-0270-07; and the Key Laboratory of Prevention, Diagnosis and Therapy of Upper Gastrointestinal Cancer of Zhejiang Province, No. 2022E10021.
Institutional review board statement: This study was approved by the Medical Ethics Committee of Zhejiang Cancer Hospital, approval No. AF-4.0/34-1.
Informed consent statement: All patients signed informed consent forms. The study was conducted in accordance with the Declaration of Helsinki (as revised in 2013).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The data that support the findings of this study are available from the corresponding author upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiang-Dong Cheng, MD, Professor, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine, Chinese Academy of Sciences, No. 1 East Banshan Road, Hangzhou 310022, Zhejiang Province, China. yezuqscx@gmail.com
Received: March 13, 2025
Revised: April 23, 2025
Accepted: May 19, 2025
Published online: June 7, 2025
Processing time: 84 Days and 19 Hours
Core Tip

Core Tip: This study highlights the log odds of positive lymph nodes (LODDS) as a reliable independent prognostic tool for moderately and poorly differentiated gastric cancer, providing more precise risk stratification than traditional systems such as pathologic N stage. Patients with higher LODDS values, which are associated with more aggressive tumor behavior, may benefit from more frequent follow-ups and intensified treatments. The incorporation of the LODDS into a clinical nomogram is expected to improve individualized survival prediction and the development of therapeutic strategies.