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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 14, 2025; 31(2): 99349
Published online Jan 14, 2025. doi: 10.3748/wjg.v31.i2.99349
Published online Jan 14, 2025. doi: 10.3748/wjg.v31.i2.99349
Trends of alkaline phosphatase to prealbumin ratio in patients with hepatitis B linked to hepatocellular carcinoma development
Wen-Chong Zhen, Xue-Ting Bai, Qian Zhang, Zi-Han Li, Yi-Xin Zhang, Rong-Xuan Xu, Wei Wu, Zhi-Han Yao, School of Public Health, Dalian Medical University, Dalian 116044, Liaoning Province, China
Jing Sun, Graduate School, Dalian Medical University, Dalian 116044, Liaoning Province, China
Chun-Wen Pu, Dalian Public Health Clinical Center, Dalian Municipal Research Institute for Public Health, Dalian 116001, Liaoning Province, China
Xiao-Feng Li, Department of Epidemiology and Health Statistics, Dalian Medical University, Dalian 116044, Liaoning Province, China
Co-first authors: Wen-Chong Zhen and Jing Sun.
Co-corresponding authors: Chun-Wen Pu and Xiao-Feng Li.
Author contributions: Zhen WC and Sun J contribute equally to this study as co-first authors; Pu CW and Li XF contribute equally to this study as co-corresponding authors; Zhen WC and Li XF designed the study and drafted the initial manuscript; Sun J participated in the statistical analysis and interpretation of the data; Bai XT, Zhang Q, Li ZH, Zhang XY, Xu RX, Wu W, Yao ZH participated in the acquisition, analysis; Pu CW Provided clinical data, Li XF performed the review and editing.
Institutional review board statement: The study was reviewed and approved by the Dalian Public Health Clinical Center Institutional Review Board (Approval No. 2024-026KY-001).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors of this research hereby confirm that there are no potential conflicts of interest to disclose.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Feng Li, PhD, Professor, Department of Epidemiology and Health Statistics, Dalian Medical University, No. 9 West Section Lvshun Road, Dalian 116044, Liaoning Province, China. lxf_chen@dmu.edu.cn
Received: July 20, 2024
Revised: October 25, 2024
Accepted: November 18, 2024
Published online: January 14, 2025
Processing time: 150 Days and 19.9 Hours
Revised: October 25, 2024
Accepted: November 18, 2024
Published online: January 14, 2025
Processing time: 150 Days and 19.9 Hours
Core Tip
Core Tip: Joint Modeling of Longitudinal and Survival data analysis revealed no association between baseline alkaline phosphatase to prealbumin ratio (APR) levels and Hepatocellular carcinoma (HCC) risk, yet a significant correlation exists between the increasing trend of APR and heightened HCC risk.