Wang Y, Liu J. Interplay between creeping fat and gut microbiota: A brand-new perspective on fecal microbiota transplantation in Crohn's disease. World J Gastroenterol 2025; 31(2): 100024 [DOI: 10.3748/wjg.v31.i2.100024]
Corresponding Author of This Article
Jie Liu, MD, Doctor, Department of Gastroenterology, The First Affiliated Hospital of University of Science and Technology of China, No. 17 Lujiang Road, Hefei 230001, Anhui Province, China. feixilj@163.com
Research Domain of This Article
Microbiology
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Jan 14, 2025; 31(2): 100024 Published online Jan 14, 2025. doi: 10.3748/wjg.v31.i2.100024
Interplay between creeping fat and gut microbiota: A brand-new perspective on fecal microbiota transplantation in Crohn's disease
Ying Wang, Jie Liu
Ying Wang, Department of Life Sciences and Medicine, South District of Endoscopic Center, The First Affiliated Hospital of University of Science and Technology of China, University of Science and Technology of China, Hefei 230001, Anhui Province, China
Jie Liu, Department of Gastroenterology, The First Affiliated Hospital of University of Science and Technology of China, Hefei 230001, Anhui Province, China
Author contributions: Ying W and Liu J contributed to draft of the manuscript; Liu J contributed to critical revision of the manuscript; all of the authors read and approved the final version of the manuscript to be published.
Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jie Liu, MD, Doctor, Department of Gastroenterology, The First Affiliated Hospital of University of Science and Technology of China, No. 17 Lujiang Road, Hefei 230001, Anhui Province, China. feixilj@163.com
Received: August 5, 2024 Revised: November 17, 2024 Accepted: November 22, 2024 Published online: January 14, 2025 Processing time: 134 Days and 17.6 Hours
Core Tip
Core Tip: Some studies have indicated that dysbiosis of the gut microbiota is a significant characteristic in the development of Crohn's disease (CD). However, the functional role of translocated microbiota in the mesenteric adipose tissue (MAT) of CD patients remains ambiguous. Evidence has shown that the translocation of viable microbiota into human MAT can polarize macrophages, leading to adipogenesis within the MAT and contributing to the formation of creeping fat (CrF) in individuals with CD. Nonetheless, it remains an important inquiry to elucidate the role of MAT-associated microbiota in the pathogenesis of CD. This manuscript aims to discuss the article by Wu et al, which explores the potential therapeutic value of fecal microbiota transplantation in the management of CD. Study by Wu et al suggested that the interactions among gut microbiota, MAT hypertrophy, and intestinal fibrosis may mutually reinforce one another in the pathogenesis of CD. Consequently, targeting MAT and CrF may hold promise as a therapeutic strategy for patients suffering from CD.
